Gasdermin D Deficiency Limits the Transition of Atherosclerotic Plaques to an Inflammatory Phenotype in <i>ApoE</i> Knock-Out Mice

Gasdermin D (GSDMD) is the key executor of pyroptotic cell death. Recent studies suggest that GSDMD-mediated pyroptosis is involved in atherosclerotic plaque destabilization. We report that cleaved GSDMD is expressed in macrophage- and smooth muscle cell-rich areas of human plaques. To determine the...

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Autores principales:	Pauline Puylaert, Melissa Van Praet, Frederik Vaes, Cédric H. G. Neutel, Lynn Roth, Pieter-Jan Guns, Guido R. Y. De Meyer, Wim Martinet
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2022-05-01
Colección:	Biomedicines
Materias:	gasdermin D pyroptosis inflammation atherosclerosis
Acceso en línea:	https://www.mdpi.com/2227-9059/10/5/1171
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