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Inhibited KdpFABC transitions into an E1 off-cycle state

KdpFABC is a high-affinity prokaryotic K+ uptake system that forms a functional chimera between a channel-like subunit (KdpA) and a P-type ATPase (KdpB). At high K+ levels, KdpFABC needs to be inhibited to prevent excessive K+ accumulation to the point of toxicity. This is achieved by a phosphorylat...

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Hoofdauteurs: Jakob M Silberberg, Charlott Stock, Lisa Hielkema, Robin A Corey, Jan Rheinberger, Dorith Wunnicke, Victor RA Dubach, Phillip J Stansfeld, Inga Hänelt, Cristina Paulino
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications Ltd 2022-10-01
Reeks:eLife
Onderwerpen:
cryo-EM
P-type ATPase
membrane transport mechanism
protein regulation
potassium uptake
structure–function
Online toegang:https://elifesciences.org/articles/80988
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