Prevention of Tumor Growth and Dissemination by In Situ Vaccination with Mitochondria‐Targeted Atovaquone

Abstract Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination approach, local injection of mitocho...

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Библиографические подробности

Главные авторы:	Mofei Huang, Donghai Xiong, Jing Pan, Qi Zhang, Yian Wang, Charles R. Myers, Bryon D. Johnson, Micael Hardy, Balaraman Kalyanaraman, Ming You
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2022-04-01
Серии:	Advanced Science
Предметы:	in situ vaccination lung cancer mitochondria‐targeted atovaquone mitochondrial bioenergetics tumor immune microenvironment
Online-ссылка:	https://doi.org/10.1002/advs.202101267
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