Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

Histone deacetylase 6 (HDAC6) is an established drug target for cancer treatment. Inhibitors of HDAC6 based on a hydroxamic acid zinc binding group (ZBG) are often associated with undesirable side effects. Herein, we describe the identification of HDAC6 inhibitors based on a completely new 3-hydroxy...

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Autori principali:	Pasquale Linciano, Luca Pinzi, Silvia Belluti, Ugo Chianese, Rosaria Benedetti, Davide Moi, Lucia Altucci, Silvia Franchini, Carol Imbriano, Claudia Sorbi, Giulio Rastelli
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2021-01-01
Serie:	Journal of Enzyme Inhibition and Medicinal Chemistry
Soggetti:	hdac6 inhibition zinc-binding-group hdac inhibitors drug design
Accesso online:	http://dx.doi.org/10.1080/14756366.2021.1981306
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