Oral bacteria induce IgA autoantibodies against a mesangial protein in IgA nephropathy model mice
This work shows that the CBX3, atypically expressed on the mesangial cell, is a target of IgA auto-Abs in IgA nephropathy model mice and patients. Such IgA auto-Abs are induced by oral bacteria in mice. IgA nephropathy (IgAN) is caused by deposition of IgA in the glomerular mesangium. The mechanism...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Life Science Alliance LLC
2024-04-01
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| Serier: | Life Science Alliance |
| Online adgang: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202402588 |
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