Beneficial effects of bempedoic acid treatment in polycystic kidney disease cells and mice

ADPKD has few therapeutic options. Tolvaptan slows disease but has side effects limiting its tolerability. Bempedoic acid (BA), an ATP citrate-lyase (ACLY) inhibitor FDA-approved for hypercholesterolemia, catalyzes a key step in fatty acid/sterol synthesis important for cell proliferation. BA is act...

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Prif Awduron:	Kenneth R. Hallows, Hui Li, Biagio Saitta, Saman Sepehr, Polly Huang, Jessica Pham, Jonathan Wang, Valeria Mancino, Eun Ji Chung, Stephen L. Pinkosky, Núria M. Pastor-Soler
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2022-11-01
Cyfres:	Frontiers in Molecular Biosciences
Pynciau:	ACLY AMPK ADPKD metabolism bempedoic acid ETC-1002
Mynediad Ar-lein:	https://www.frontiersin.org/articles/10.3389/fmolb.2022.1001941/full
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!