Inhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

Abstract Background Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remains < 40%, hig...

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Bibliografski detalji

Glavni autori:	Donna L. Nile, Colin Rae, David J. Walker, Joe Canning Waddington, Isabel Vincent, Karl Burgess, Mark N. Gaze, Robert J. Mairs, Anthony J. Chalmers
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2021-05-01
Serija:	Cancer & Metabolism
Teme:	Neuroblastoma Radiation Metabolism 2-DG Metformin 131I-MIBG
Online pristup:	https://doi.org/10.1186/s40170-021-00258-5
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