Partial reduction of amyloid β production by β-secretase inhibitors does not decrease synaptic transmission

Abstract Background Alzheimer’s disease (AD) is the most common form of age-related neurodegenerative diseases. Cerebral deposition of Aβ peptides, especially Aβ42, is considered the major neuropathological hallmark of AD and the putative cause of AD-related neurotoxicity. Aβ peptides are produced b...

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Bibliografske podrobnosti

Principais autores:	Tugce Munise Satir, Lotta Agholme, Anna Karlsson, Mattias Karlsson, Paul Karila, Sebastian Illes, Petra Bergström, Henrik Zetterberg
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2020-05-01
Serija:	Alzheimer’s Research & Therapy
Teme:	BACE inhibition Synaptic transmission Alzheimer’s disease Amyloid beta Beta-secretase
Online dostop:	http://link.springer.com/article/10.1186/s13195-020-00635-0
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