Investigating G-quadruplex structures in RPGR gene: Implications for understanding X-linked retinal degeneration

Aims: This pilot study investigates the potential pathogenic role of G-quadruplex (G4) structures in RPGR-associated retinal degeneration, starting from a case of suspected X-linked form affected family. We hypothesize that the stabilization of these structures might alter DNA replication and transc...

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Auteurs principaux:	Luigi Donato, Concetta Scimone, Simona Alibrandi, Domenico Mordà, Ivan Anchesi, Sergio Zaccaria Scalinci, Carmela Rinaldi, Rosalia D'Angelo, Antonina Sidoti
Format:	Artigo
Langue:	Inglês
Publié:	Elsevier 2024-04-01
Collection:	Heliyon
Sujets:	G-quadruplex RPGR WGA Pyridostatin DNA-Polymerase RNA-Polymerase
Accès en ligne:	http://www.sciencedirect.com/science/article/pii/S2405844024058596
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