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Computational modeling of DLBCL predicts response to BH3-mimetics

Abstract In healthy cells, pro- and anti-apoptotic BCL2 family and BH3-only proteins are expressed in a delicate equilibrium. In contrast, this homeostasis is frequently perturbed in cancer cells due to the overexpression of anti-apoptotic BCL2 family proteins. Variability in the expression and sequ...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Ielyaas Cloete, Victoria M. Smith, Ross A. Jackson, Andrea Pepper, Chris Pepper, Meike Vogler, Martin J. S. Dyer, Simon Mitchell
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: Nature Portfolio 2023-06-01
Цуврал:npj Systems Biology and Applications
Онлайн хандалт:https://doi.org/10.1038/s41540-023-00286-5
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