Single-cell profiling identifies a pro-tumoral VCAN positive macrophage subset and defines a prognostic signature in glioblastoma

Abstract Glioblastoma (GBM), the most aggressive primary brain tumor, develops within a tumor microenvironment (TME) dominated by tumor-associated macrophages (TAMs) that critically influence disease progression. Through single-cell RNA sequencing (scRNA-seq) and bioinformatic analysis, we delineate...

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Auteurs principaux:	Jiaxin Guo, Zhansheng Zhu, Nanyang Tong, Dingding Xu, Huan Zhang, Chenshi Lin, Guiping Wan, Yamei Wang, Qingqing Zhou, Liang Xia
Format:	Artigo
Langue:	Inglês
Publié:	Springer 2026-05-01
Collection:	Discover Oncology
Sujets:	Glioblastoma Macrophage VCAN⁺ macrophage subpopulation Single-cell RNA sequencing Immune microenvironment
Accès en ligne:	https://doi.org/10.1007/s12672-026-05166-y
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