Haploinsufficiency of NR3C1 drives glucocorticoid resistance in adult acute lymphoblastic leukemia cells by down-regulating the mitochondrial apoptosis axis, and is sensitive to Bcl-2 blockage

Abstract Background Relapse represents the leading cause of death in both child and adult patients with acute lymphoblastic leukemia (ALL). Development of chemo-resistance is ultimately responsible for treatment failure and relapse, therefore understanding the molecular basis underlying resistance i...

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主要な著者:	Haowen Xiao, Yingying Ding, Yang Gao, Li-Mengmeng Wang, Huafang Wang, Lijuan Ding, Xiaoqing Li, Xiaohong Yu, He Huang
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2019-08-01
シリーズ:	Cancer Cell International
主題:	Haploinsufficiency NR3C1 Glucocorticoid resistance Acute lymphoblastic leukemia Mitochondrial apoptosis axis Bcl-2 blockage
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12935-019-0940-9
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