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Triptolide Induces Glioma Cell Autophagy and Apoptosis via Upregulating the ROS/JNK and Downregulating the Akt/mTOR Signaling Pathways

Apoptosis and autophagy are the two prominent forms of developmental cell death, and researches have shown that crosstalk exists between these two processes. A prior study demonstrated that triptolide inhibited the proliferation of malignant glioma cells. However, whether apoptosis and autophagy par...

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Principais autores: Xihong Liu, Peiyuan Zhao, Xiujuan Wang, Lei Wang, Yingjun Zhu, Wei Gao
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2019-05-01
סדרה:Frontiers in Oncology
נושאים:
triptolide
apoptosis
autophagy
LC3
ROS
גישה מקוונת:https://www.frontiersin.org/article/10.3389/fonc.2019.00387/full
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