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Neuropathological stages of neuronal, astrocytic and oligodendrocytic alpha-synuclein pathology in Parkinson’s disease

Abstract Alpha-synucleinopathies are neurodegenerative diseases characterized by the spread of alpha-synuclein (α-syn) aggregates throughout the central nervous system in a stereotypical manner. These diseases include Lewy body disease (LBD), which encompass Dementia with Lewy bodies (DLB), Parkinso...

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Principais autores: Maria Otero-Jimenez, Marcelina J. Wojewska, Lawrence P. Binding, Simona Jogaudaite, Sandra Gray-Rodriguez, Alexandra L. Young, Steve Gentleman, Javier Alegre-Abarrategui
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-02-01
coleção:Acta Neuropathologica Communications
Assuntos:
Alpha-synuclein
Alpha-synucleinopathies
Parkinson’s disease
Astrocytes
Neuroanatomical distribution
Staging
Acesso em linha:https://doi.org/10.1186/s40478-025-01944-x
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