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EFHC1, implicated in juvenile myoclonic epilepsy, functions at the cilium and synapse to modulate dopamine signaling

Neurons throughout the mammalian brain possess non-motile cilia, organelles with varied functions in sensory physiology and cellular signaling. Yet, the roles of cilia in these neurons are poorly understood. To shed light into their functions, we studied EFHC1, an evolutionarily conserved protein re...

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Kaydedildi:
Asıl Yazarlar: Catrina M Loucks, Kwangjin Park, Denise S Walker, Andrea H McEwan, Tiffany A Timbers, Evan L Ardiel, Laura J Grundy, Chunmei Li, Jacque-Lynne Johnson, Julie Kennedy, Oliver E Blacque, William Schafer, Catharine H Rankin, Michel R Leroux
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: eLife Sciences Publications Ltd 2019-02-01
Seri Bilgileri:eLife
Konular:
EFHC1
juvenile myoclonic epilepsy
cilia
synapse
Caenorhabditis elegans
Online Erişim:https://elifesciences.org/articles/37271
Etiketler: Etiketle
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