Lineage-Biased Stem Cells Maintain Estrogen-Receptor-Positive and -Negative Mouse Mammary Luminal Lineages

Delineating the mammary differentiation hierarchy is important for the study of mammary gland development and tumorigenesis. Mammary luminal cells are considered a major origin of human breast cancers. However, how estrogen-receptor-positive (ER+) and ER− luminal cells are developed and maintained r...

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Autori principali:	Chunhui Wang, John R. Christin, Maja H. Oktay, Wenjun Guo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2017-03-01
Serie:	Cell Reports
Soggetti:	mammary stem cells stem cell hierarchy mammary gland development mammary differentiation breast cancer cancer cell-of-origin estrogen receptor positive cancer estrogen receptor negative cancer lineage tracing mammary gland regeneration
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2211124717302899
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