Designed miniproteins potently inhibit and protect against MERS-CoV

Summary: Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic pathogen with a 36% case-fatality rate in humans. No vaccines or specific therapeutics are currently approved for use in humans or the camel host reservoir. Here, we computationally designed monomeric and homo-oligomeric...

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Bibliografiske detaljer

Principais autores:	Robert J. Ragotte, M. Alejandra Tortorici, Nicholas J. Catanzaro, Amin Addetia, Brian Coventry, Heather M. Froggatt, Jimin Lee, Cameron Stewart, Jack T. Brown, Inna Goreshnik, Jeremiah N. Sims, Lukas F. Milles, Basile I.M. Wicky, Matthias Glögl, Stacey Gerben, Alex Kang, Asim K. Bera, William Sharkey, Alexandra Schäfer, Jack R. Harkema, Ralph S. Baric, David Baker, David Veesler
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2025-06-01
Serier:	Cell Reports
Fag:	CP: Immunology
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2211124725005315
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