Peripheral CD4+ T cell phenotype and brain microglial activation associated with cognitive heterogeneity in aged rats

Abstract Cognitive decline is a critical hallmark of brain aging. Although aging is a natural process, there is significant heterogeneity in cognition levels among individuals; however, the underlying mechanisms remain uncertain. In our study, we classified aged male Sprague‒Dawley rats into aged co...

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Hlavní autoři:	Lian Yu, Miao-Miao Liu, Mei-Qi Guan, Rui Wang, Xiao-Rong Yang, Xiu-Min Zhang, Jing-Jing Wei, Shu-Fen Wu, Hong Gu, Qiang Fu, Jun-Hong Guo, Yan-Li Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-11-01
Edice:	Immunity & Ageing
Témata:	Aging-associated cognitive decline Cognitive heterogeneity Microglial activation Th17/Treg cells Inflammation
On-line přístup:	https://doi.org/10.1186/s12979-024-00486-5
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