Prediction of a CLDN18.2 Targeted Antibody Drug Conjugate Pharmacokinetics in Cancer Patients Using PBPK Modeling and Simulation
ABSTRACT Antibody‐drug conjugates (ADCs) represent a promising anticancer approach. Although physiologically based pharmacokinetics (PBPK) modeling became essential in Pharmacometrics to characterize exposure in different tissues, very few PBPK models have been published for ADCs, none within the PK...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Wiley
2025-09-01
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| Col·lecció: | CPT: Pharmacometrics & Systems Pharmacology |
| Matèries: | |
| Accés en línia: | https://doi.org/10.1002/psp4.70071 |
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