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PGE2 binding to EP2 promotes ureteral stone expulsion by relaxing ureter via the cAMP-PKA pathway

Abstract Background This study investigated the relaxation effect of PGE2 on the ureter and its role in promoting calculi expulsion following calculi development. Methods By using immunofluorescence and Western blot, we were able to locate EP receptors in the ureter. In vitro experiments assessed th...

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Main Authors: Hao Su, Wenyan Zhou, Weiming Chen, Ke Yang, Meng Yang, Hu He, Cheng Qian, Dongbo Yuan, Kehua Jiang, Jianguo Zhu
Format: Artigo
Language:Inglês
Published: BMC 2024-06-01
Series:BMC Urology
Subjects:
PGE2
EP2
cAMP
Ureteral Calculi
Relaxation
Online Access:https://doi.org/10.1186/s12894-024-01504-w
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