Specific Determinants of the Transmembrane Region of the Andes Virus Gc Glycoprotein Drive the Transition from Membrane Hemifusion to Pore Formation

Andes virus (ANDV), a highly pathogenic orthohantavirus, enters host cells through low pH–triggered membrane fusion mediated by the Gc glycoprotein, a class II fusion protein containing a single C-terminal transmembrane domain (TMD). While the ectodomain has been extensively characterized, the role...

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Autori principali:	Chantal L. Márquez, Fernando Villalón-Letelier, Gianina Arata-Salas, Nicole D. Tischler
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-05-01
Serie:	Viruses
Soggetti:	hantavirus virus:cell membrane fusion intermediate membrane fusion steps transmembrane domain
Accesso online:	https://www.mdpi.com/1999-4915/18/6/633
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