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The SAMHD1-mediated block of LINE-1 retroelements is regulated by phosphorylation

Abstract Background The restriction factor SAMHD1 regulates intracellular nucleotide level by degrading dNTPs and blocks the replication of retroviruses and DNA viruses in non-cycling cells, like macrophages or dendritic cells. In patients, inactivating mutations in samhd1 are associated with the au...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Alexandra Herrmann, Sabine Wittmann, Dominique Thomas, Caitlin N. Shepard, Baek Kim, Nerea Ferreirós, Thomas Gramberg
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-03-01
Schriftenreihe:Mobile DNA
Schlagworte:
LINE-1
SAMHD1
Endogenous retroelements
Restriction factor
Aicardi-Goutières syndrome
Intrinsic immunity
Online-Zugang:http://link.springer.com/article/10.1186/s13100-018-0116-5
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