Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy

Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-specific stimulator YC-1 induce a 71° rotatio...

Полное описание

Библиографические подробности

Главные авторы:	Benjamin G Horst, Adam L Yokom, Daniel J Rosenberg, Kyle L Morris, Michal Hammel, James H Hurley, Michael A Marletta
Формат:	Artigo
Язык:	Inglês
Опубликовано:	eLife Sciences Publications Ltd 2019-09-01
Серии:	eLife
Предметы:	CryoEM nitric oxide cyclic GMP manduca sexta allostery SAXS
Online-ссылка:	https://elifesciences.org/articles/50634
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