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Cardiac desmosomal adhesion relies on ideal-, slip- and catch bonds

Abstract The cardiac muscle consists of individual cardiomyocytes that are mechanically linked by desmosomes. Desmosomal adhesion is mediated by densely packed and organized cadherins which, in presence of Ca2+, stretch out their extracellular domains (EC) and dimerize with opposing binding partners...

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Bibliographic Details
Main Authors: Manuel Göz, Sylvia M. Steinecker, Greta M. Pohl, Volker Walhorn, Hendrik Milting, Dario Anselmetti
Format: Artigo
Language:Inglês
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-52725-w
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