Design of an equilibrative nucleoside transporter subtype 1 inhibitor for pain relief

Abstract The current opioid crisis urgently calls for developing non-addictive pain medications. Progress has been slow, highlighting the need to uncover targets with unique mechanisms of action. Extracellular adenosine alleviates pain by activating the adenosine A1 receptor (A1R). However, efforts...

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Detalles Bibliográficos

Principais autores:	Nicholas J. Wright, Yutaka Matsuoka, Hyeri Park, Wei He, Caroline G. Webster, Kenta Furutani, Justin G. Fedor, Aidan McGinnis, Yiquan Zhao, Ouyang Chen, Sangsu Bang, Ping Fan, Ivan Spasojevic, Jiyong Hong, Ru-Rong Ji, Seok-Yong Lee
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Portfolio 2024-12-01
Series:	Nature Communications
Acceso en liña:	https://doi.org/10.1038/s41467-024-54914-7
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