Astrocyte matricellular proteins that control excitatory synaptogenesis are regulated by inflammatory cytokines and correlate with paralysis severity during experimental autoimmune encephalomyelitis

The matricellular proteins, secreted protein acidic and rich in cysteine (SPARC) and SPARC-like 1 (SPARCL1), are produced by astrocytes and control excitatory synaptogenesis in the central nervous system. While SPARCL1 directly promotes excitatory synapse formation in vitro and in the developing ne...

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Detalhes bibliográficos

Principais autores:	Pennelope K. Blakely, Shabbir eHussain, Lindsey E. Carlin, David N. Irani
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2015-10-01
coleção:	Frontiers in Neuroscience
Assuntos:	Astrocytes Multiple Sclerosis synaptic plasticity EAE SPARC SPARCL1
Acesso em linha:	http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00344/full
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