Design and synthesis of 1,4,8-triazaspiro[4.5]decan-2-one derivatives as novel mitochondrial permeability transition pore inhibitors

Ischaemia/reperfusion injury (IRI) is a condition that occurs when tissues from different organs undergo reperfusion following an ischaemic event. The mitochondrial permeability transition pore (mPTP), a multiprotein platform including structural components of ATP synthase with putative gate functio...

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Detalles Bibliográficos

Principais autores:	Valentina Albanese, Gaia Pedriali, Martina Fabbri, Antonella Ciancetta, Silvia Ravagli, Chiara Roccatello, Remo Guerrini, Giampaolo Morciano, Delia Preti, Paolo Pinton, Salvatore Pacifico
Formato:	Artigo
Idioma:	Inglês
Publicado:	Taylor & Francis Group 2025-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	Permeability transition pore cytoprotection cardiac ischaemia/reperfusion injury mitochondria mPTP inhibitors
Acceso en liña:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2505907
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