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Metabolic engineering of Corynebacterium glutamicum for producing branched chain amino acids

Abstract Background Branched chain amino acids (BCAAs) are widely applied in the food, pharmaceutical, and animal feed industries. Traditional chemical synthetic and enzymatic BCAAs production in vitro has been hampered by expensive raw materials, harsh reaction conditions, and environmental polluti...

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Main Authors: Shengzhu Yu, Bo Zheng, Zhenya Chen, Yi-Xin Huo
Format: Artigo
Language:Inglês
Published: BMC 2021-12-01
Series:Microbial Cell Factories
Subjects:
Corynebacterium glutamicum
BCAAs biosynthesis
Metabolic engineering
Feedback inhibition
Acetohydroxy acid synthase
Online Access:https://doi.org/10.1186/s12934-021-01721-0
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