Control of feeding behavior by modified retrograde AAV to the gastrointestinal tract nerve afferents

Abstract Vagal afferents originating in the upper gastrointestinal (GI) tract convey critical satiety signals but have remained challenging to target with precision. Here, we exploited a modified retrograde AAV2/rh10 vector delivered to the gastric wall to selectively transduce stomach-innervating n...

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Autors principals:	Roberta Marongiu, Jingjing Wang, Santiago R. Unda, Julie Barbera, Leandra Velazquez, Rosemary Li, Maria Jimenez-Gonzalez, William Tower, Neranjan de Silva, Rachel Retik, Sarah A. Stanley, Michael G. Kaplitt
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-12-01
Col·lecció:	Scientific Reports
Matèries:	AAV vectors Vagal afferent Nucleus tractus solitarius Nodose ganglion Neuronal modulation
Accés en línia:	https://doi.org/10.1038/s41598-025-31377-4
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