Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

Genome stability is jeopardized by imbalances of the dNTP pool; such imbalances affect the rate of fork progression. For example, cytidine deaminase (CDA) deficiency leads to an excess of dCTP, slowing the replication fork. We describe here a novel mechanism by which pyrimidine pool disequilibrium c...

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Главные авторы:	Simon Gemble, Akshay Ahuja, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Julien Dairou, Denis S F Biard, Sarah Lambert, Massimo Lopes, Mounira Amor-Guéret
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Public Library of Science (PLoS) 2015-07-01
Серии:	PLoS Genetics
Online-ссылка:	http://europepmc.org/articles/PMC4504519?pdf=render
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