PRMT6 is required for initiating and amplifying macrophage-induced inflammation in heterotopic ossification by increasing CCL2 expression

Abstract Heterotopic ossification (HO) is a debilitating disorder marked by ectopic bone formation in soft tissues, frequently triggered by inflammation after trauma. While macrophage-driven inflammation plays a critical role in HO pathogenesis, the molecular mechanisms governing its initiation, amp...

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Autori principali:	Wenxiang Chu, Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yang Li, Bangke Zhang, Liang Wang, Haibin Wang, Chaofeng Han, Xuhua Lu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 2026-03-01
Serie:	Bone Research
Accesso online:	https://doi.org/10.1038/s41413-026-00512-w
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