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Expression and function of S100A8/A9 (calprotectin) in human typhoid fever and the murine Salmonella model.

BACKGROUND:Typhoid fever, caused by the Gram-negative bacterium Salmonella enterica serovar Typhi, is a major cause of community-acquired bacteremia and death worldwide. S100A8 (MRP8) and S100A9 (MRP14) form bioactive antimicrobial heterodimers (calprotectin) that can activate Toll-like receptor 4,...

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Principais autores: Hanna K De Jong, Ahmed Achouiti, Gavin C K W Koh, Christopher M Parry, Stephen Baker, Mohammed Abul Faiz, Jaap T van Dissel, Albert M Vollaard, Ester M M van Leeuwen, Joris J T H Roelofs, Alex F de Vos, Johannes Roth, Tom van der Poll, Thomas Vogl, Willem Joost Wiersinga
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2015-04-01
Serier:PLoS Neglected Tropical Diseases
Online adgang:http://europepmc.org/articles/PMC4393299?pdf=render
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