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Targeting the gut to improve seizure control in CDKL5 deficiency disorder (CDD): study protocol for a single-arm, open-label clinical trial

IntroductionCyclin-dependent kinase-like 5 deficiency disorder (CDD) is a neurodevelopmental condition characterized by infantile-onset epilepsy, developmental delay, intellectual and motor disabilities, sleep disturbances, and cortical visual impairment. Currently, there is no treatment for CDD, an...

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Principais autores: Francesca Triva, Elisa Borghi, Matteo Domenico Marsiglia, Emerenziana Ottaviano, Emilia Ricci, Paola Tognini, Marco Montecucco, Aglaia Vignoli
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2025-10-01
סדרה:Frontiers in Neurology
נושאים:
CDKL5 deficiency disorder
gut microbiota
seizures
gut-brain axis
sleep disturbance
drug resistant epilepsy
גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fneur.2025.1642329/full
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