Allele-specific quantification of human leukocyte antigen transcript isoforms by nanopore sequencing

IntroductionWhile tens of thousands of HLA alleles have been identified by DNA sequencing, the contribution of alternative splicing to HLA diversity is not well characterized. In this study, we sought to determine if long-read sequencing could be used to accurately quantify allele-specific HLA trans...

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Autors principals:	Andrew E. O. Hughes, Maureen C. Montgomery, Chang Liu, Eric T. Weimer
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-08-01
Col·lecció:	Frontiers in Immunology
Matèries:	human leukocyte antigen (HLA) nanopore sequencing long-read sequencing transcript isoforms allele-specific expression
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1199618/full
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