Calcineurin regulates aldosterone production via dephosphorylation of NFATC4

The mineralocorticoid aldosterone, secreted by the adrenal zona glomerulosa (ZG), is critical for life, maintaining ion homeostasis and blood pressure. Therapeutic inhibition of protein phosphatase 3 (calcineurin, Cn) results in inappropriately low plasma aldosterone levels despite concomitant hyper...

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Autors principals:	Mesut Berber, Sining Leng, Agnieszka Wengi, Denise V. Winter, Alex Odermatt, Felix Beuschlein, Johannes Loffing, David T. Breault, David Penton
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Clinical investigation 2023-07-01
Col·lecció:	JCI Insight
Matèries:	Endocrinology Metabolism
Accés en línia:	https://doi.org/10.1172/jci.insight.157027
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