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Haplotype Analysis of the T-Cell Receptor Beta (TCRB) Locus by Long-amplicon TCRB Repertoire Sequencing

Background: Polymorphism within the human T-cell receptor beta variable (TRBV) gene has been proposed as a risk factor for autoimmune disease and immune-related adverse events (IRAEs) during immunotherapy. Previous efforts to evaluate TRBV polymorphism by whole genome sequencing have been hampered b...

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Asıl Yazarlar: Timothy J Looney, Dzifa Y Duose, Geoffrey Lowman, Elizabeth Linch, Joud Hajjar, Denise Topacio-Hall, Mingxuan Xu, Jianping Zheng, Anas Alshawa, Coya Tapia, Bettzy Stephen, Linghua Wang, Funda Meric-Bernstam, Lauren Miller, Alexander Glavin, Lifeng Lin, Jing Gong, Jeffrey Conroy, Carl Morrison, Fiona Hyland, Aung Naing
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Innovative Healthcare Institute 2019-09-01
Seri Bilgileri:Journal of Immunotherapy and Precision Oncology
Konular:
immune-related adverse events
immunotherapy
polymorphism
t-cell receptor
Online Erişim:https://jipo.org/doi/pdf/10.4103/JIPO.JIPO_16_19
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