Synthesis, SAR, and multi-target evaluation of isonicotinoyl hydrazones as potent MPO/AChE inhibitors and metal chelators for Alzheimer’s disease

Abstract Isonicotinoyl hydrazone derivatives (1–20) were synthesized and evaluated for their inhibitory activities against myeloperoxidase (MPO) and acetylcholinesterase (AChE), antioxidant activity, metal ion chelation, regulation of reactive oxygen species, and cytoprotective activity, with the ai...

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Hlavní autoři:	Zeyang Wei, Zhenguo Liu, Ying Chang, Zixiao Wang, Bo Guo, Xiaojiao Ma, Kai Zhao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Portfolio 2026-04-01
Edice:	Scientific Reports
Témata:	Isonicotinoyl hydrazone Antioxidant Acetylcholinesterase Myeloperoxidase Biometal chelation Molecular docking
On-line přístup:	https://doi.org/10.1038/s41598-026-45771-z
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