A novel TNKS/USP25 inhibitor blocks the Wnt pathway to overcome multi-drug resistance in TNKS-overexpressing colorectal cancer

Modulating Tankyrases (TNKS), interactions with USP25 to promote TNKS degradation, rather than inhibiting their enzymatic activities, is emerging as an alternative/specific approach to inhibit the Wnt/β-catenin pathway. Here, we identified UAT-B, a novel neoantimycin analog isolated from Streptomyce...

Volledige beschrijving

Bibliografische gegevens

Hoofdauteurs:	Hongrui Zhu, Yamin Gao, Liyun Liu, Mengyu Tao, Xiao Lin, Yijia Cheng, Yaoyao Shen, Haitao Xue, Li Guan, Huimin Zhao, Li Liu, Shuping Wang, Fan Yang, Yongjun Zhou, Hongze Liao, Fan Sun, Houwen Lin
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2024-01-01
Reeks:	Acta Pharmaceutica Sinica B
Onderwerpen:	Colorectal cancer TNKS–USP25 interaction Multi-drug resistance TNKS overexpression Wnt pathway Apoptosis
Online toegang:	http://www.sciencedirect.com/science/article/pii/S2211383523004070
Tags:	Voeg label toe Geen labels, Wees de eerste die dit record labelt!