Autocrine IGF-1/IGF-1R signaling is responsible for constitutive PI3K/Akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody

Background Alterations in the PI3K/Akt pathway are found in a wide range of cancers and the development of PI3K inhibitors represents a promising approach to cancer therapy. Constitutive PI3K activation, reflecting an intrinsic oncogenic deregulation of primary blast cells, is detected in 50% of pat...

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Detalhes bibliográficos

Principais autores:	Nicolas Chapuis, Jérôme Tamburini, Pascale Cornillet-Lefebvre, Lucile Gillot, Valérie Bardet, Lise Willems, Sophie Park, Alexa S Green, Norbert Ifrah, François Dreyfus, Patrick Mayeux, Catherine Lacombe, Didier Bouscary
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Ferrata Storti Foundation 2010-03-01
coleção:	Haematologica
Acesso em linha:	https://haematologica.org/article/view/5527
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