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Stress-Inducible Transcription Factor NUPR1 Is Involved in the Inhibitory Effects Exerted by Statins on Insulin Action in ER-Positive Breast Cancer Cells

Obesity is frequently associated with metabolic alterations like hypercholesterolemia and hyperinsulinemia and represents a major risk factor for several diseases, including breast cancer (BC). Insulin signaling, as well as the frequent overexpression of the insulin receptor (IR), play a key role in...

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Principais autores: Domenica Scordamaglia, Azzurra Zicarelli, Francesca Cirillo, Marianna Talia, Ernestina Marianna De Francesco, Roberta Malaguarnera, Marcello Maggiolini, Rosamaria Lappano
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-02-01
Serier:Cells
Fag:
breast cancer
statins
BCAHC-1 cells
insulin
insulin receptor
Online adgang:https://www.mdpi.com/2073-4409/15/3/284
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