T-cell exhaustion indicator characterizes the tumor microenvironment landscape and predicts colon adenocarcinoma prognosis via integrating single-cell RNA-seq and bulk RNA-sequencing

Abstract Background Colon adenocarcinoma (COAD) is the most common type of colon cancer, posing a significant threat to public health. In the tumor microenvironment (TME), T cells differentiate into terminally exhausted T cells (TEX), but the relationship between TEX and COAD has not been fully eluc...

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Autori principali:	Haifeng Sun, Ning Hu, Shaowei Ma, Yu Zheng, Ren Niu, Wenya Zhu, Shaofan Qiu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	BMC Cancer
Soggetti:	T cell exhaustion Colon adenocarcinoma FAT4 Tumor microenvironment CD8 + T cells
Accesso online:	https://doi.org/10.1186/s12885-025-15535-5
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