Metformin combined with local irradiation provokes abscopal effects in a murine rectal cancer model

Abstract Although preoperative chemoradiation therapy can down-stage locally advanced rectal cancer (LARC), it has little effect on distant metastases. Metformin exerts an anti-cancer effect partly through the activation of host immunity. LuM1, a highly lung metastatic subclone of colon 26, was inje...

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主要な著者:	Mineyuki Tojo, Hideyo Miyato, Koji Koinuma, Hisanaga Horie, Hidenori Tsukui, Yuki Kimura, Yuki Kaneko, Hideyuki Ohzawa, Hironori Yamaguchi, Kotaro Yoshimura, Alan Kawarai Lefor, Naohiro Sata, Joji Kitayama
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2022-05-01
シリーズ:	Scientific Reports
オンライン･アクセス:	https://doi.org/10.1038/s41598-022-11236-2
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