A pathway-informed mutual exclusivity framework to detect genetic interactions in pediatric cancer

Abstract Background The exponential increase of sequenced cancer genomes has enabled the in-silico study of genetic interactions in tumors across many cancer types—particularly synthetic lethality, where two gene alterations lead to cell death—and identify new candidate therapeutic targets. This ris...

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Hlavní autoři:	Anastasia Spinou, Richard Gremmen, Jarno Drost, Patrick Kemmeren
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-12-01
Edice:	BMC Medical Genomics
Témata:	Genetic interactions Pediatric cancer Mutual exclusivity Synthetic lethality Pathways
On-line přístup:	https://doi.org/10.1186/s12920-025-02289-z
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