Organoids in translation: a bench-to-bedside framework for pancreatic cancer precision medicine

Abstract Introduction Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with a 5-year survival rate of < 13%. Standard treatments such as FOLFIRINOX or gemcitabine/nab-paclitaxel yield modest response rates, underscoring the urgent need for precision oncology approaches....

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Autori principali:	Danial A Malik, Emily A.S Schmieder, Gina Genova, Jeremey Gaskins, Robert C.G. Martin II
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	Journal of Translational Medicine
Soggetti:	Pancreatic ductal adenocarcinoma Patient-derived organoids Precision oncology Translational research Drug screening Biomarker development
Accesso online:	https://doi.org/10.1186/s12967-025-07596-8
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