Therapeutic siRNA targeting PLIN2 ameliorates steatosis, inflammation, and fibrosis in steatotic liver disease models

Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide. If left untreated, MASLD can progress from simple hepatic steatosis to metabolic dysfunction–associated steatohepatitis, which is characterized by inflammation and fibrosis. Curren...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yao Wang, Jiaxin Zhou, Qi Yang, Xinmeng Li, Yifu Qiu, Yansong Zhang, Min Liu, Alan Jian Zhu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-10-01
Schriftenreihe:	Journal of Lipid Research
Schlagworte:	fibrosis GalNAc-siRNA hepatic steatosis inflammation MASLD PLIN2
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S0022227524001408
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!