Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions
Abstract Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious, almost all protein-coding genes lack detectable signals of negative selection. This raises the question of how tumors tolerate such large amounts...
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| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2023-06-01
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| Reeks: | Nature Communications |
| Online toegang: | https://doi.org/10.1038/s41467-023-39313-8 |
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