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Therapeutic leukapheresis with severe pertussis: evaluating efficacy, feasibility, and safety

Abstract Background Severe pertussis with hyperleukocytosis (WBC ≥ 50 × 109/L) carries high mortality in infants. While exchange transfusion (ET) is a commonly recommended intervention, it is resource-intensive and non-selective. Therapeutic leukapheresis (TL) offers targeted leukoreduction but lack...

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Principais autores: Yixin Gao, Ding Liu, Zitian Lu, Zhijiang Chen, Gang Wang, Minghui Yang, Linyan Wu, Shaowen Li, Yongzheng Peng, Guoqiang Liang
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-05-01
Serier:BMC Pediatrics
Fag:
Therapeutic Leukapheresis
Severe Pertussis
Exchange Transfusion
Hyperleukocytosis
Infants
Online adgang:https://doi.org/10.1186/s12887-026-06896-2
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