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The adverse effects associated with semaglutide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis

Abstract Background Semaglutide’s disease-specific weight-reducing effects are well established, but its adverse effects, which may not be disease-specific, have not been systematically assessed. The aim of this review was to assess the adverse effects associated with semaglutide use compared with p...

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Autori principali: Christina Dam Bjerregaard Sillassen, Johanne Juul Petersen, Pascal Faltermeier, Delal Yucel, Faiza Siddiqui, Rebecca Kjær Andersen, Leonardo Graever, Jonas Leth Bjerg, Caroline Barkholt Kamp, Johannes Grand, Helena Dominguez, Anne Frølich, Peter Gæde, Christian Gluud, Ole Mathiesen, Janus Christian Jakobsen
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-11-01
Serie:BMC Medicine
Soggetti:
Semaglutide
Placebo
Safety
Systematic review
Meta-analysis
Trial sequential analysis
Accesso online:https://doi.org/10.1186/s12916-025-04486-0
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