Identification of Ras-degrading small molecules that inhibit the transformation of colorectal cancer cells independent of β-catenin signaling

Colorectal cancer: Finding new small molecule drug candidates Mutations in KRAS, a gene regulating cell proliferation, occur in 40–50% of colorectal cancer (CRC) patients. These cancers are usually insensitive to antibody drugs targeting the epidermal growth factor receptor (EGFR) on cancer cells. K...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Wookjin Shin, Sang-Kyu Lee, Jeong-Ha Hwang, Jong-Chan Park, Yong-Hee Cho, Eun Ji Ro, Yeonhwa Song, Haeng Ran Seo, Kang-Yell Choi
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Publishing Group 2018-06-01
Rangatū:	Experimental and Molecular Medicine
Urunga tuihono:	https://doi.org/10.1038/s12276-018-0102-5
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!