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Evidence of Different IL-1β Activation Pathways in Innate Immune Cells From Indeterminate and Cardiac Patients With Chronic Chagas Disease

Background: Chagas cardiomyopathy is the main fibrosing myocarditis among known heart diseases. Development of cardiomyopathy has been related to extracellular matrix (ECM) remodeling, which are controlled by matrix metalloproteinases (MMPs) and cytokines, especially interleukin (IL)-1β. The convert...

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Principais autores: Nayara I. Medeiros, Bruna F. Pinto, Silvana M. Elói-Santos, Andréa Teixeira-Carvalho, Luísa M. D. Magalhães, Walderez O. Dutra, Rodrigo Correa-Oliveira, Juliana A. S. Gomes
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-04-01
Serier:Frontiers in Immunology
Fag:
IL-1β activation pathways
caspase-1-independent
gelatinases
Chagas disease
chagasic cardiomyopathy
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2019.00800/full
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